Informatics Methodology and Secondary Analyses for Immunology Data in ImmPort (UH2 Clinical Trial Not Allowed) | PAR 19 229

Opportunity Information: Apply for PAR 19 229

The NIH funding opportunity PAR 19 229, titled "Informatics Methodology and Secondary Analyses for Immunology Data in ImmPort (UH2 Clinical Trial Not Allowed)," is a discretionary, cooperative agreement mechanism focused on getting more value out of immunology data that already exist in the ImmPort repository. The program is designed to push forward practical informatics methods and tools that make shared immunology datasets easier to find, reuse, combine, and analyze, while also funding rigorous secondary analyses that use existing ImmPort data to answer meaningful basic or clinical immunology research questions. The "Clinical Trial Not Allowed" designation signals that the funded work should not involve prospective clinical trial activities; instead, the emphasis is on computational, methodological, and secondary analytic work using existing data resources.

A central aim of the FOA is the development or improvement of informatics approaches that enable better reuse of ImmPort data. In practice, this can include new software tools, analytical pipelines, data harmonization methods, metadata standards support, approaches for integrating multiple studies, and improved ways to manage, curate, or interpret complex immunology data types. The expectation is that funded projects will contribute methods that help the broader research community work more effectively with shared datasets, reducing barriers such as inconsistent formatting, incomplete metadata, or difficulties combining immunological assays and clinical phenotypes across studies.

In parallel with tool and method development, the FOA supports secondary analyses of existing immunology datasets housed in ImmPort. These projects are meant to mine and reanalyze previously collected data to generate new insights without collecting new primary clinical trial data. The secondary analyses can address both basic and clinically relevant immunology questions, such as identifying immune correlates, characterizing immune response patterns, comparing outcomes across cohorts, or testing hypotheses that become possible only when multiple datasets are aggregated. The emphasis is on maximizing scientific return on investment from data that have already been generated and shared.

The award is issued as a cooperative agreement (UH2), which generally indicates substantial scientific or programmatic involvement by NIH staff compared to a standard grant. While the provided source text does not list the full project structure or milestones, cooperative agreements typically come with clearer expectations for coordination, deliverables, and collaborative engagement with the program, particularly when the goal is to produce reusable tools or community-facing resources. The listed award ceiling is $200,000, and the original closing date shown is 2019-10-01, indicating the opportunity as described was tied to that application window.

Eligibility is broad across U.S.-based organizations and includes many common applicant types: state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized tribal governments; tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (excluding institutions of higher education when specified in the category); for-profit organizations other than small businesses; small businesses; and other eligible entities. The FOA also explicitly calls out additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, Indian/Native American Tribal Governments (other than federally recognized), and U.S. territories or possessions.

At the same time, there are clear restrictions related to foreign participation. Non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply. Non-domestic components of U.S. organizations are also not eligible, and foreign components as defined by the NIH Grants Policy Statement are not allowed. These limits indicate that the work must be led and carried out within eligible domestic organizational structures without foreign components as part of the funded project.

Overall, this FOA is aimed at strengthening the ecosystem around ImmPort by funding two complementary kinds of work: (1) informatics methodology and tool building that improves the usability and interoperability of shared immunology datasets, and (2) high-value secondary analyses that leverage existing ImmPort studies to answer new immunology questions. The combined effect is intended to improve data reuse, accelerate discovery, and make shared immunology data more actionable for the broader research community.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "Informatics Methodology and Secondary Analyses for Immunology Data in ImmPort (UH2 Clinical Trial Not Allowed)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855.
• This funding opportunity was created on 2019-03-22.
• Applicants must submit their applications by 2019-10-01. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $200,000.00 in funding.
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PAR 19 229

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