Opportunity Information: Apply for RFA DA 25 050
The National Institutes of Health (NIH) is soliciting applications under an SBIR funding opportunity titled "Solutions to enable diagnosis and treatment of adverse health consequences of non-disordered drug use (R43/R44 - Clinical Trial Optional)" (Funding Opportunity Number: RFA-DA-25-050; CFDA: 93.279). This is a discretionary grant program intended specifically for U.S. small business concerns that can research and develop practical tools, technologies, or service-ready approaches that help clinicians and health systems identify, manage, and treat harmful health effects that can occur among people who use drugs but do not meet criteria for a drug use disorder. The focus is on reducing negative health outcomes and lowering the broader impact of these consequences through solutions that can realistically be integrated into healthcare services.
A central theme of the opportunity is translation into real-world care: projects should be designed with implementation in mind, meaning they should fit into clinical workflows, be feasible for health providers to adopt, and ultimately be accessible to the people who need them. NIH signals that affordability and accessibility are priorities, so applicants are expected to think beyond technical performance and address practical barriers such as cost, ease of use, scalability, and deployment in settings that commonly serve people who use drugs (for example, primary care, emergency departments, community clinics, harm reduction-linked clinical services, or other front-line healthcare environments). Proposed solutions may be entirely new technologies or may involve repurposing or adapting existing tools and platforms to better meet the needs of this population.
The mechanism is the SBIR R43/R44 pathway, which typically supports a staged development process where early work (often aligned with feasibility and proof-of-concept) can progress toward further development and validation steps. The NOFO notes that clinical trials are optional, which means applicants can propose studies that do or do not include clinical trial components, depending on what is appropriate for the maturity of the solution and the evidence needed to move it toward use in healthcare. The emphasis is on developing solutions that measurably improve health outcomes related to adverse consequences of non-disordered drug use, whether through better diagnosis, monitoring, linkage to appropriate treatment, or other clinically relevant interventions.
Eligibility is limited to small businesses, consistent with SBIR rules. Foreign organizations (non-U.S. entities) are not eligible to apply, and non-U.S. components of U.S. organizations are also not eligible to apply. However, foreign components, as defined by the NIH Grants Policy Statement, may be allowed in certain circumstances, which typically means discrete project elements can be carried out outside the U.S. only when strongly justified and permitted under NIH policy. The opportunity was created on 2024-06-13, and the original application closing date is 2024-12-02. The listing does not specify an award ceiling or the expected number of awards in the provided source data, so applicants would need to consult the full NOFO for budget guidance, project period limits, and any institute-specific considerations tied to RFA-DA-25-050.Apply for RFA DA 25 050
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Solutions to enable diagnosis and treatment of adverse health consequences of non-disordered drug use (R43/R44 - Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279.
- This funding opportunity was created on 2024-06-13.
- Applicants must submit their applications by 2024-12-02. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses.
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| Solutions to enable diagnosis and treatment of adverse health consequences of non-disordered drug use (R41/R42 - Clinical Trial Optional) Apply for RFA DA 25 049 Funding Number: RFA DA 25 049 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Mechanisms of Reciprocal Interactions between HIV Associated Neuroinflammation and CNS Persistence: Implications in HIV Neuropathogenesis and Cure (R01 Clinical Trial Not Allowed) Apply for RFA MH 25 180 Funding Number: RFA MH 25 180 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Mechanisms of Reciprocal Interactions between HIV Associated Neuroinflammation and CNS Persistence: Implications in HIV Neuropathogenesis and Cure (R21 Clinical Trial Not Allowed) Apply for RFA MH 25 181 Funding Number: RFA MH 25 181 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Enhancing Mechanistic Research on Precision Probiotic Therapies (R61/R33 Clinical Trial Optional) Apply for PAR 24 238 Funding Number: PAR 24 238 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Enhancing Mechanistic Research on Precision Probiotic Therapies (R33 Clinical Trial Optional) Apply for PAR 24 239 Funding Number: PAR 24 239 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Mechanistic Studies to Investigate the Interrelationship Between Sleep and/or Circadian Rhythms and Substance Use Disorders (R01 Clinical Trials Not Allowed) Apply for RFA DA 25 045 Funding Number: RFA DA 25 045 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Mechanistic Studies to Investigate the Interrelationship Between Sleep and/or Circadian Rhythms and Substance Use Disorders (R01 Basic Experimental Studies with Humans Required) Apply for RFA DA 25 044 Funding Number: RFA DA 25 044 Agency: National Institutes of Health Category: Education, Health Funding Amount: $300,000 |
| Novel Preclinical Models of NeuroHIV in the cART Era (R61/R33 - Clinical Trial Not Allowed) Apply for RFA NS 24 035 Funding Number: RFA NS 24 035 Agency: National Institutes of Health Category: Education, Health Funding Amount: $600,000 |
| Combined Neuromodulation and Behavioral Treatment Algorithm Development for Stimulant Use Disorder (StUD) Enriched for Vulnerable Phenotype (U01 Clinical Trial Required) Apply for RFA DA 25 057 Funding Number: RFA DA 25 057 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| D-START: Data Science Track Award for Research Transition (D/START) (R03-Clinical Trial Optional) Apply for PAS 24 242 Funding Number: PAS 24 242 Agency: National Institutes of Health Category: Education, Health Funding Amount: $1,000,000 |
| Translational Resource Centers to Build Bridges Between Substance Use Epidemiology/Etiology and Prevention Intervention Research (U24 Clinical Trials Not Allowed) Apply for RFA DA 25 085 Funding Number: RFA DA 25 085 Agency: National Institutes of Health Category: Education, Health Funding Amount: $350,000 |
| National Cancer Institute Youth Enjoy Science Research Education Program (R25 Clinical Trial Not Allowed) Apply for RFA CA 24 026 Funding Number: RFA CA 24 026 Agency: National Institutes of Health Category: Education, Health Funding Amount: $400,000 |
| Successor-in-Interest (Type 6 Parent Clinical Trial Optional) Apply for PA 24 253 Funding Number: PA 24 253 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Device Based Treatments for Substance Use Disorders (UG3/UH3 Clinical Trial Optional) Apply for PAR 25 023 Funding Number: PAR 25 023 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| Translating Socioenvironmental Influences on Neurocognitive Development and Addiction Risk (TranSINDA) (U01 Clinical Trial Not Allowed) Apply for RFA DA 25 037 Funding Number: RFA DA 25 037 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Translating Socioenvironmental Influences on Neurocognitive Development and Addiction Risk (TranSINDA) (U24 Clinical Trial Not Allowed) Apply for RFA DA 25 038 Funding Number: RFA DA 25 038 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC) Organizational Research Education Award to Promote Diversity (UE5 - Clinical Trial Not Allowed) Apply for PAR 24 224 Funding Number: PAR 24 224 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| RNA Modifications Driving Oncogenesis (RNAMoDO; U01 Clinical Trial Not Allowed) Apply for RFA CA 24 029 Funding Number: RFA CA 24 029 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NCI Outstanding Investigator Award (R35) Apply for PAR 15 342 Funding Number: PAR 15 342 Agency: National Institutes of Health Category: Education, Health Funding Amount: $600,000 |
| AIDS-Science Track Award for Research Transition (R03) Apply for PA 15 290 Funding Number: PA 15 290 Agency: National Institutes of Health Category: Education, Health Funding Amount: $100,000 |
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