Promoting Viral Suppression among Individuals from Health Disparity Populations Engaged in HIV Care (R01 Clinical Trial Required) | RFA MD 23 007

Opportunity Information: Apply for RFA MD 23 007

The NIH funding opportunity RFA-MD-23-007, titled "Promoting Viral Suppression among Individuals from Health Disparity Populations Engaged in HIV Care (R01 Clinical Trial Required)," is a discretionary grant program that supports health research projects focused on improving HIV outcomes among people already connected to HIV medical care. The central goal is to test interventions that increase antiretroviral therapy (ART) initiation, strengthen ART adherence over time, and ultimately achieve and maintain viral suppression. The program is specifically aimed at people living with HIV from health disparity populations who reside in geographic areas experiencing high rates of new HIV infections, reflecting a focus on communities where transmission remains elevated and where inequities in HIV outcomes persist despite the availability of effective treatment.

This opportunity uses the NIH R01 research project grant mechanism and explicitly requires a clinical trial, meaning applicants are expected to propose and conduct a rigorous, intervention-based study in humans where participants are prospectively assigned to receive a strategy or program intended to improve ART uptake, adherence, or viral suppression. In practical terms, competitive projects would typically evaluate real-world approaches such as patient navigation, culturally tailored adherence support, care coordination models, behavioral or technology-enabled adherence interventions, structural interventions that reduce barriers to treatment, or multi-component programs delivered in clinics and community-linked settings. Because the target population is already engaged in HIV care, the work is less about initial diagnosis and linkage and more about closing the gap between being "in care" and reaching consistent viral suppression, which is the key clinical outcome for individual health and for preventing onward transmission.

Eligible applicants span a broad set of U.S.-based organizations and governmental units, including state, county, and city or township governments; special district governments; independent school districts; and public housing authorities/Indian housing authorities. Higher education institutions are eligible, including public and state-controlled institutions, private institutions of higher education, and designated-serving institutions such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). Tribal entities may apply, including federally recognized Native American tribal governments as well as tribal organizations and Indian/Native American tribal governments that are not federally recognized. Nonprofit organizations are eligible whether or not they hold 501(c)(3) status, and both for-profit organizations (other than small businesses) and small businesses are also listed as eligible. The announcement also notes eligibility for faith-based or community-based organizations, regional organizations, and eligible agencies of the federal government, as well as U.S. territories or possessions, underscoring an intent to support interventions that can be developed and tested by a wide range of partners close to affected communities.

Foreign eligibility is limited. Non-domestic (non-U.S.) entities and non-domestic components of U.S. organizations are not eligible to apply as applicant organizations under this announcement. At the same time, "foreign components" as defined by the NIH Grants Policy Statement are allowed, which generally means a U.S. applicant may include certain international elements of the project when they are scientifically justified and meet NIH policy requirements, but the main applicant organization must be domestic and the project cannot be led by a non-U.S. institution.

Administratively, the sponsoring agency is the National Institutes of Health, the funding instrument is a grant, and the activity category is health (CFDA 93.307). The opportunity was created on February 10, 2023, with an original closing date of April 3, 2023. The excerpted source data does not specify an award ceiling or the expected number of awards, so applicants would typically need to consult the full funding announcement for budget guidance, project period expectations, and any institute- or program-specific review considerations. Overall, the program is designed to generate strong evidence on practical interventions that help people in health disparity populations who are already in HIV care start ART promptly, stay adherent, and reach durable viral suppression, especially in places where the burden of new infections remains high.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "Promoting Viral Suppression among Individuals from Health Disparity Populations Engaged in HIV Care (R01 Clinical Trial Required)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.307.
• This funding opportunity was created on 2023-02-10.
• Applicants must submit their applications by 2023-04-03. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA MD 23 007

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