Opportunity Information: Apply for PAR 18 743
The Pilot and Feasibility Clinical Research Grants in Urologic Disorders (R21 Clinical Trial Optional), funding opportunity number PAR 18 743, is a National Institutes of Health discretionary grant program designed to support early-stage, small-scale clinical and translational research focused on urologic disorders. It uses the NIH Exploratory/Developmental Research Grant mechanism (R21), which is typically meant for projects that are still in the pilot or feasibility phase, where preliminary human data, proof-of-concept results, or foundational clinical evidence are needed before moving into a larger and more definitive study. The announcement explicitly allows, but does not require, clinical trials, meaning applicants can propose either clinical trial work or other types of clinical or translational studies as long as the work is directly relevant to urologic disorders and is positioned as exploratory or developmental rather than full-scale.
The scientific scope is broad but centered on clinical and public health importance. Projects may include pilot clinical studies, feasibility assessments, translational investigations, epidemiological studies, or early clinical trials that address meaningful questions in prevention, diagnosis, prognosis, or treatment of urologic disorders. A key theme of the program is future leverage: NIH anticipates that some funded R21 projects will produce the data and operational groundwork necessary to justify and design larger studies later on, such as full-scale epidemiological investigations, validation of diagnostic strategies, or randomized clinical trials. In other words, the program is aimed at supporting the kind of smaller, well-justified studies that can de-risk a bigger clinical research agenda by showing early signals of impact, confirming feasibility, refining endpoints, or clarifying recruitment and retention realities.
The opportunity is categorized under Health (and also listed under Food and Nutrition, Health) with CFDA number 93.847, and it is offered as a grant funding instrument. The listed award ceiling is $200,000, indicating the maximum funding level expected under the announcement. While the source data does not specify the number of expected awards, it does indicate the program’s intent to fund projects that can generate clinically useful knowledge and create a bridge to later-stage, more resource-intensive research efforts.
Eligibility is intentionally expansive, reflecting NIH’s broad applicant base. Eligible applicants include a wide range of government entities (state, county, city or township, and special district governments), independent school districts, public and state-controlled institutions of higher education, private institutions of higher education, and federally recognized Native American tribal governments. It also includes public housing authorities/Indian housing authorities, Native American tribal organizations that are not federally recognized tribal governments, and both nonprofit organizations (with or without 501(c)(3) status) and for-profit organizations (other than small businesses), as well as small businesses and other applicant types. In addition, the FOA explicitly calls out other eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), eligible federal agencies, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and even non-U.S. entities (foreign organizations). This wide eligibility suggests NIH is encouraging participation across many institutional settings, including community and underserved-serving organizations that may have unique access to patient populations or clinical settings relevant to urologic disorders.
Key timing details from the source information include an original closing date of September 7, 2020, and a creation date of April 4, 2018. While those dates reflect the specific posting referenced in the source data, the main takeaway for a prospective applicant is the program’s purpose and fit: it is meant for pilot and feasibility clinical and translational studies in urologic disorders with clear potential to inform or launch larger, high-impact clinical research down the line.Apply for PAR 18 743
- The National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "Pilot and Feasibility Clinical Research Grants in Urologic Disorders (R21 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847.
- This funding opportunity was created on 2018-04-04.
- Applicants must submit their applications by 2020-09-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: Pilot and Feasibility Clinical Research Grants in Urologic Disorders (R21 Clinical Trial Optional) - PAR 18 743
What is the name of this grant opportunity?
The opportunity is titled Pilot and Feasibility Clinical Research Grants in Urologic Disorders (R21 Clinical Trial Optional).
What is the funding opportunity number (FOA number)?
The funding opportunity number is PAR 18 743.
Which agency offers this opportunity?
This is a National Institutes of Health (NIH) discretionary grant program.
What type of grant mechanism does this use?
It uses the NIH Exploratory/Developmental Research Grant (R21) mechanism, which is designed for exploratory or developmental projects that are still in the pilot or feasibility stage.
What is the main purpose of this R21 program?
The program supports early-stage, small-scale clinical and translational research focused on urologic disorders, particularly work that can generate preliminary human data, proof-of-concept results, or foundational clinical evidence needed to justify larger, more definitive studies later.
Is a clinical trial required?
No. The announcement is clinical trial optional, meaning applicants may propose a clinical trial, but they are not required to do so.
What kinds of studies are considered a good fit?
The scope is broad as long as it stays centered on urologic disorders and is positioned as exploratory/developmental. Examples mentioned include:
- Pilot clinical studies
- Feasibility assessments
- Translational investigations
- Epidemiological studies
- Early clinical trials
What topic areas can the proposed research address?
Projects may address meaningful questions in prevention, diagnosis, prognosis, or treatment of urologic disorders, with an emphasis on clinical and public health importance.
What does NIH mean by "pilot" or "feasibility" in this context?
In this program, "pilot" or "feasibility" refers to smaller, well-justified studies intended to:
- Generate early clinical signals or preliminary human data
- Demonstrate whether a larger study is practical
- Refine endpoints or study procedures
- Clarify recruitment and retention realities
- Establish foundational evidence to support later research
What is the "future leverage" theme described in the announcement?
A major goal is for funded R21 projects to create a bridge to later-stage research by producing data and operational groundwork that can support larger efforts later, such as:
- Full-scale epidemiological investigations
- Validation of diagnostic strategies
- Randomized clinical trials
What is the maximum award amount listed for this opportunity?
The listed award ceiling is $200,000, described as the maximum funding level expected under the announcement.
How many awards will be made?
The source information does not specify the number of expected awards.
What is the assistance listing or CFDA number associated with this opportunity?
The opportunity is listed with CFDA number 93.847.
What is the funding instrument for this opportunity?
The funding instrument is a grant.
What category is this opportunity listed under?
It is categorized under Health (and also listed under Food and Nutrition, Health).
Who is eligible to apply?
Eligibility is broad. The source information lists many eligible applicant types, including:
- State, county, city or township, and special district governments
- Independent school districts
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Federally recognized Native American tribal governments
- Public housing authorities/Indian housing authorities
- Native American tribal organizations that are not federally recognized tribal governments
- Nonprofit organizations (with or without 501(c)(3) status)
- For-profit organizations (other than small businesses)
- Small businesses
- Other applicant types (as referenced in the source)
- Alaska Native and Native Hawaiian Serving Institutions
- Asian American Native American Pacific Islander Serving Institutions (AANAPISI)
- Hispanic-serving Institutions
- Historically Black Colleges and Universities (HBCUs)
- Tribally Controlled Colleges and Universities (TCCUs)
- Eligible federal agencies
- Faith-based or community-based organizations
- Regional organizations
- U.S. territories or possessions
- Non-U.S. entities (foreign organizations)
Are foreign (non-U.S.) organizations eligible?
Yes. The source information explicitly includes non-U.S. entities (foreign organizations) among eligible applicants.
Are for-profit entities eligible?
Yes. The source information includes for-profit organizations (other than small businesses) and also lists small businesses as eligible.
Are community-based or faith-based organizations eligible?
Yes. The source information explicitly includes faith-based or community-based organizations among eligible applicants.
Are minority-serving institutions specifically mentioned as eligible?
Yes. The source information explicitly calls out multiple categories, including HBCUs, Hispanic-serving Institutions, AANAPISI, Alaska Native and Native Hawaiian Serving Institutions, and TCCUs.
Does the program focus only on large, definitive clinical trials?
No. The program is designed for exploratory or developmental work (pilot and feasibility) rather than full-scale definitive studies, although it can support early clinical trials when appropriate.
What is the creation date shown for this opportunity?
The source information lists a creation date of April 4, 2018.
What closing date is shown in the source information?
The source information lists an original closing date of September 7, 2020.
How should applicants interpret the listed dates?
Based on the source information, the dates reflect the specific posting referenced. The key takeaway provided is the program's purpose and fit: supporting pilot and feasibility clinical and translational studies in urologic disorders that can inform and launch larger, high-impact clinical research later.
What is the core "fit test" for a proposed project under this FOA?
The project should be directly relevant to urologic disorders, be small-scale and early-stage (pilot/feasibility), and be positioned to generate knowledge or practical groundwork that can support larger later-stage studies.
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| Pilot and Feasibility Clinical Research Grants in Kidney Diseases (R21 Clinical Trial Optional) Apply for PAR 18 744 Funding Number: PAR 18 744 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $200,000 |
| Understanding Skeletal Effects of Type 1 Diabetes (R01 Clinical Trial Optional) Apply for RFA DK 18 002 Funding Number: RFA DK 18 002 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $400,000 |
| Regenerative Medicine Innovation Projects (RMIP) (U44 - Clinical Trial Not Allowed) Apply for RFA HL 18 035 Funding Number: RFA HL 18 035 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $225,000 |
| Regenerative Medicine Innovation Projects (RMIP) Investigator-Initiated Studies (Collaborative U01 Clinical Trial Not Allowed) Apply for RFA HL 18 030 Funding Number: RFA HL 18 030 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $250,000 |
| Regenerative Medicine Innovation Projects (RMIP) (UT2 - Clinical Trial Not Allowed) Apply for RFA HL 18 033 Funding Number: RFA HL 18 033 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $225,000 |
| Regenerative Medicine Innovation Projects (RMIP) Investigator-Initiated Clinical Trials (UG3/UH3 Clinical Trial Required) Apply for RFA HL 18 031 Funding Number: RFA HL 18 031 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $405,000 |
| New Paradigms in Tissue Communication-from mediators to metabolic function (RC2 Clinical Trials Optional) Apply for PAR 18 886 Funding Number: PAR 18 886 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Elucidating the Role of the Autonomic Nervous System in Peripheral Metabolism and Metabolic Disease through the Application of Novel Tools and Methodologies (RC2 Clinical Trial Optional) Apply for PA 18 891 Funding Number: PA 18 891 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Elucidating the Role of the Autonomic Nervous System in Peripheral Metabolism and Metabolic Disease through the Application of Novel Tools and Methodologies (RC2 Clinical Trial Optional) Apply for PAR 18 898 Funding Number: PAR 18 898 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Human Islet Research Network - Consortium on Human Islet Biomimetics (HIRN-CHIB) (UG3/UH3 Clinical Trial Not Allowed) Apply for RFA DK 18 011 Funding Number: RFA DK 18 011 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $750,000 |
| Pilot and Feasibility Clinical and Translational Research Studies in Digestive Diseases and Nutrition (R21 Clinical Trial Optional) Apply for PA 18 903 Funding Number: PA 18 903 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $200,000 |
| Limited Competition for the Continuation of the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) Clinical Centers (U01 Clinical Trial Required) Apply for RFA DK 18 505 Funding Number: RFA DK 18 505 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $2,000,000 |
| Limited Competition for the Continuation of the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) Data Coordinating Center (U24 Clinical Trial Required) Apply for RFA DK 18 506 Funding Number: RFA DK 18 506 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $2,000,000 |
| Limited Competition for the Continuation of Cure Glomerulonephropathy (CureGN) Data Coordinating Center (U24 Clinical Trial Not Allowed) Apply for RFA DK 18 504 Funding Number: RFA DK 18 504 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $1,000,000 |
| Limited Competition for the Continuation of Cure Glomerulonephropathy (CureGN) Participating Clinical Centers (U01 Clinical Trial Not Allowed) Apply for RFA DK 18 503 Funding Number: RFA DK 18 503 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $750,000 |
| Limited Competition for the Continuation of the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network Discovery Sites (U01 Clinical Trial Not Allowed) Apply for RFA DK 18 513 Funding Number: RFA DK 18 513 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Limited Competition for the Continuation of the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network Data Coordinating Core (DCC) (U24 Clinical Trial Not Allowed) Apply for RFA DK 18 514 Funding Number: RFA DK 18 514 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Limited Competition for the Continuation of the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network Tissue and Technology Core (TATC) (U24 Clinical Trial Not Allowed) Apply for RFA DK 18 515 Funding Number: RFA DK 18 515 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Limited Competition for the Continuation of the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Research Sites (U01 Clinical Trial Not Allowed) Apply for RFA DK 18 510 Funding Number: RFA DK 18 510 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $375,000 |
| Limited Competition for the Continuation of the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Data Coordinating Center (U24 Clinical Trial Not Allowed) Apply for RFA DK 18 511 Funding Number: RFA DK 18 511 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $800,000 |
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