Opportunity Information: Apply for RFA CA 21 041
The Pancreatic Ductal Adenocarcinoma (PDAC) Stromal Reprogramming Consortium (PSRC) funding opportunity (RFA-CA-21-041) is a National Institutes of Health (NIH) discretionary grant solicitation that supports coordinated, consortium-style research focused on the tumor stroma in pancreatic ductal adenocarcinoma. It uses the U01 cooperative agreement mechanism, which typically means NIH program staff will have substantial scientific involvement in the project beyond standard grant stewardship, often including coordination across awardees, shared milestones, and collaborative participation in consortium governance. Clinical trials are not allowed under this announcement, so the supported work is intended to be preclinical, translational, mechanistic, or otherwise non-trial human research aimed at enabling future therapeutic strategies rather than testing interventions in a clinical trial framework.
The scientific emphasis signaled by the title is stromal reprogramming in PDAC, meaning the opportunity is aimed at understanding and therapeutically leveraging the non-cancerous cellular and extracellular components surrounding pancreatic tumors. In PDAC, the stroma can be unusually dense and biologically active, affecting immune infiltration, drug delivery, tumor metabolism, and signaling interactions that drive progression and treatment resistance. A consortium structured around "stromal reprogramming" generally implies projects that investigate how to alter stromal states or functions to make tumors more vulnerable to treatment, less immunosuppressive, or otherwise less supportive of malignant growth. Because the vehicle is a consortium, applicants are usually expected to contribute complementary expertise, standardized approaches, and data or resource sharing that advance the field more efficiently than isolated projects.
Administratively, the opportunity is categorized under Education and Health as the activity category and is tied to CFDA numbers 93.394 and 93.395, which correspond to NIH/NCI assistance programs. The funding instrument type is a cooperative agreement, and the agency listed is NIH. The original closing date for applications was 2021-11-01, and the opportunity record shows an award ceiling of $600,000. The listing also includes an "ExpectedAwards" field, but no number is provided in the source data you shared, so the total number of anticipated awards is not specified here.
Eligibility is broad and includes many common applicant types across government, academia, nonprofit, and industry. Eligible applicants include state governments; county governments; city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; public housing authorities and Indian housing authorities; Native American tribal organizations that are not federally recognized tribal governments; nonprofits with 501(c)(3) status (excluding institutions of higher education); nonprofits without 501(c)(3) status (excluding institutions of higher education); for-profit organizations other than small businesses; small businesses; and an "Others" category that is further expanded in the description. The description explicitly adds additional eligible applicant groups, including Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISIs); eligible agencies of the federal government; faith-based or community-based organizations; Hispanic-serving institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American tribal governments other than federally recognized; non-domestic (non-U.S.) entities (foreign organizations); regional organizations; Tribally Controlled Colleges and Universities (TCCUs); and applicants located in a U.S. territory or possession. Taken together, this indicates the program is open to a wide range of organizational structures, including domestic and international entities, and explicitly includes multiple institution types that serve historically underrepresented communities.
In practical terms, a strong-fit applicant would be an organization (or a lead organization coordinating collaborators) that can contribute rigorously to a multi-site, coordinated research effort aimed at deciphering and manipulating PDAC stromal biology, while operating within the constraints of a non-clinical-trial U01 cooperative framework. Applicants would typically need the infrastructure to participate in consortium activities, align with shared standards where required, and deliver well-defined research outputs that collectively support the overarching goal of stromal reprogramming approaches for pancreatic cancer.Apply for RFA CA 21 041
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Pancreatic Ductal Adenocarcinoma (PDAC) Stromal Reprogramming Consortium (PSRC) (U01 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.394, 93.395.
- This funding opportunity was created on 2021-07-26.
- Applicants must submit their applications by 2021-11-01. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $600,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the PDAC Stromal Reprogramming Consortium (PSRC) funding opportunity?
The Pancreatic Ductal Adenocarcinoma (PDAC) Stromal Reprogramming Consortium (PSRC) funding opportunity (RFA-CA-21-041) is an NIH discretionary grant solicitation supporting coordinated, consortium-style research focused on the tumor stroma in pancreatic ductal adenocarcinoma.
Which agency is offering this grant?
The agency listed for this opportunity is the National Institutes of Health (NIH).
What type of funding mechanism does this opportunity use?
This opportunity uses the U01 cooperative agreement mechanism. A cooperative agreement typically involves substantial scientific involvement from NIH program staff beyond standard grant stewardship, including coordination across awardees, shared milestones, and participation in consortium governance activities.
Is this a standard grant or a cooperative agreement?
It is a cooperative agreement (U01), meaning NIH staff are expected to be more actively involved in the scientific coordination and management of the funded projects than under many standard grant mechanisms.
What is the main scientific focus of this opportunity?
The scientific emphasis is stromal reprogramming in PDAC. This centers on understanding and therapeutically leveraging the non-cancerous cellular and extracellular components around pancreatic tumors (the tumor stroma).
What does "stromal reprogramming" mean in the context of PDAC?
In this context, stromal reprogramming generally refers to investigating how to alter stromal states or functions to make PDAC tumors more vulnerable to treatment, less immunosuppressive, or otherwise less supportive of malignant growth.
Why is the tumor stroma important in pancreatic ductal adenocarcinoma?
In PDAC, the stroma can be unusually dense and biologically active. It can influence immune infiltration, drug delivery, tumor metabolism, and signaling interactions that contribute to disease progression and treatment resistance.
Are clinical trials allowed under this announcement?
No. Clinical trials are not allowed under this announcement.
If clinical trials are not allowed, what kinds of studies are intended to be supported?
The supported work is intended to be preclinical, translational, mechanistic, or other non-trial human research aimed at enabling future therapeutic strategies rather than testing interventions in a clinical trial framework.
What does "consortium-style" research imply for applicants?
Because this opportunity is structured as a consortium, applicants are generally expected to contribute complementary expertise and participate in coordinated efforts, which may include standardized approaches, shared milestones, and sharing of data or resources to advance the field more efficiently than isolated projects.
What activity category is associated with this opportunity?
The opportunity is categorized under Education and Health as the activity category.
What CFDA numbers are associated with this opportunity?
This opportunity is tied to CFDA numbers 93.394 and 93.395, which correspond to NIH/NCI assistance programs.
What is the application closing date shown for this opportunity?
The original closing date for applications was 2021-11-01.
What is the award ceiling listed for this opportunity?
The opportunity record shows an award ceiling of $600,000.
How many awards are expected to be made?
The listing includes an "ExpectedAwards" field, but no number is provided in the information available here. Based on the provided record, the total number of anticipated awards is not specified.
Who is eligible to apply for this opportunity?
Eligibility is broad and includes a wide range of applicant types across government, academia, nonprofit, and industry. Eligible applicants include state governments; county governments; city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; public housing authorities and Indian housing authorities; Native American tribal organizations that are not federally recognized tribal governments; nonprofits with 501(c)(3) status (excluding institutions of higher education); nonprofits without 501(c)(3) status (excluding institutions of higher education); for-profit organizations other than small businesses; small businesses; and additional groups explicitly listed in the description.
Are small businesses eligible to apply?
Yes. Small businesses are listed as eligible applicants.
Are for-profit organizations eligible to apply?
Yes. For-profit organizations other than small businesses are listed as eligible, and small businesses are also listed as eligible.
Are nonprofit organizations eligible to apply?
Yes. Nonprofits with 501(c)(3) status (excluding institutions of higher education) and nonprofits without 501(c)(3) status (excluding institutions of higher education) are eligible.
Are institutions of higher education eligible to apply?
Yes. Public and state-controlled institutions of higher education and private institutions of higher education are eligible.
Are minority-serving institutions included in the eligible applicant types?
Yes. The description explicitly includes multiple institution types serving historically underrepresented communities, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
Are tribal governments and tribal organizations eligible?
Yes. Federally recognized Native American tribal governments are eligible, and the description also includes Indian/Native American tribal governments other than federally recognized as well as Native American tribal organizations that are not federally recognized tribal governments.
Are non-U.S. (foreign) organizations eligible to apply?
Yes. The description explicitly includes non-domestic (non-U.S.) entities (foreign organizations) as eligible applicants.
Are applicants in U.S. territories or possessions eligible?
Yes. The description explicitly includes applicants located in a U.S. territory or possession.
Are federal government agencies eligible to apply?
Yes. The description explicitly includes eligible agencies of the federal government.
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are explicitly listed among the additional eligible applicant groups in the description.
What would characterize a strong-fit applicant for this opportunity?
A strong-fit applicant would be an organization (or a lead organization coordinating collaborators) that can contribute rigorous research toward deciphering and manipulating PDAC stromal biology, while also being prepared to operate within a coordinated, non-clinical-trial U01 cooperative agreement framework that may include consortium participation, alignment with shared standards, and delivery of well-defined research outputs.
What kinds of collaboration and coordination might be expected under the U01 consortium structure?
Based on the cooperative agreement and consortium framing, participation may involve coordination across awardees, shared milestones, collaborative participation in consortium governance, and data or resource sharing to support common goals related to stromal reprogramming in PDAC.
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| Coordinating Center for Canine Cancer Immunotherapy Network (K9CIN; U24 Clinical Trial Not Allowed) Apply for RFA CA 21 051 Funding Number: RFA CA 21 051 Agency: National Institutes of Health Category: Education, Health Funding Amount: $375,000 |
| Advancing Validated Drug Targets for Substance Use Disorders (R41/R42 - Clinical Trial Not Allowed) Apply for RFA DA 22 018 Funding Number: RFA DA 22 018 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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| Division of Cancer Biology Multi-Consortia Coordinating Center (U24 Clinical Trial Not Allowed) Apply for RFA CA 21 049 Funding Number: RFA CA 21 049 Agency: National Institutes of Health Category: Education, Health Funding Amount: $1,200,000 |
| Research Centers for Cancer Systems Biology (U54 Clinical Trial Not Allowed) Apply for RFA CA 21 048 Funding Number: RFA CA 21 048 Agency: National Institutes of Health Category: Education, Health Funding Amount: $1,500,000 |
| Imaging - Science Track Award for Research Transition (I/START) (R03- Clinical Trial Optional) Apply for PAR 21 310 Funding Number: PAR 21 310 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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| Coordinating and Data Management Center for Acquired Resistance to Therapy Network (ARTNet; U24 Clinical Trial Not Allowed) Apply for RFA CA 21 053 Funding Number: RFA CA 21 053 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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| Fentanyl and its Analogs: Effects and Consequences for Treatment of Addiction and Overdose (UG3/UH3 Clinical Trial Optional) Apply for RFA DA 22 022 Funding Number: RFA DA 22 022 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC) Institutionally-Focused Research Education Award to Promote Diversity (UE5 - Clinical Trial Not Allowed) Apply for PAR 21 277 Funding Number: PAR 21 277 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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| Implementation Science for Cancer Control in People Living with HIV in Low- and Middle-Income Countries (U01 Clinical Trial Optional) Apply for RFA CA 21 056 Funding Number: RFA CA 21 056 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| Cancer Research Education Grants Program - Courses for Skills Development (R25 Clinical Trial Not Allowed) Apply for PAR 21 278 Funding Number: PAR 21 278 Agency: National Institutes of Health Category: Education, Health Funding Amount: $300,000 |
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