Enhancing the Use of the All of Us Research Programs Data (R21 Clinical Trial Not Allowed) | RFA PM 23 001

Opportunity Information: Apply for RFA PM 23 001

The National Institutes of Health (NIH), through the Office of the Director and its All of Us Research Program, offered this grant opportunity to help researchers make stronger, more innovative use of data housed in the All of Us Researcher Workbench. The overall aim is to advance research that aligns with high-priority mission areas across NIH Institutes, Centers, and Offices by encouraging projects that either apply established analytic approaches to existing All of Us data or push the field forward by creating new computational approaches that expand what can be learned from the dataset. This specific announcement uses the R21 mechanism and is labeled "Clinical Trial Not Allowed," meaning the work is intended to be exploratory and methods-focused rather than running interventional clinical trials.

This R21 opportunity is centered on developing new methods, models, and tools and then demonstrating their value by applying them to analyses within the All of Us Researcher Workbench environment. A key expectation is that the tools produced under this funding track are not just one-off scripts for a single research team, but resources that can be made broadly available to the wider scientific community. In practice, that means applicants are expected to think about usability, reproducibility, and portability within the Workbench context, so other researchers can adopt the new approach to accelerate discovery and expand the impact of the All of Us dataset.

NIH positioned this funding as one of two companion announcements. While this R21 is intended for new tool or method development plus application, a companion R03 announcement supports projects that analyze All of Us data using standard, established methods and approaches. Together, the pair of announcements covers both immediate scientific use of currently available data (R03) and longer-term capability building that improves how the community can analyze the data going forward (R21).

Eligibility is broad and includes many types of domestic applicants such as state, county, and local governments; special district governments; independent school districts; public and private institutions of higher education; federally recognized tribal governments; tribal organizations that are not federally recognized; public housing authorities; nonprofits with and without 501(c)(3) status; for-profit organizations (other than small businesses) and small businesses; and other entities. The announcement also explicitly highlights additional eligible applicant categories, including Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities, Asian American Native American Pacific Islander Serving Institutions, Tribally Controlled Colleges and Universities, eligible federal agencies, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and even non-U.S. entities (foreign organizations). This wide eligibility reflects the program's interest in expanding who participates in research using All of Us data and who contributes tools that make the data more accessible and useful.

Administrative details in the source information identify the opportunity as a discretionary NIH grant (Funding Opportunity Number RFA-PM-23-001) with an original closing date of March 1, 2023, and a creation date of December 23, 2022. The listing associates the opportunity with multiple CFDA numbers tied to NIH programs, underscoring that the scientific areas supported could span many NIH mission domains. While the summary provided does not list an award ceiling or the expected number of awards, the central message of the opportunity is clear: build and validate new analytic capabilities inside the All of Us Researcher Workbench, and ensure those capabilities can be shared so the broader research community can use them to generate insights from the All of Us dataset.

• The National Institutes of Health in the education, food and nutrition, health, income security and social services sector is offering a public funding opportunity titled "Enhancing the Use of the All of Us Research Programs Data (R21 Clinical Trial Not Allowed)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121, 93.172, 93.173, 93.213, 93.233, 93.242, 93.273, 93.279, 93.286, 93.307, 93.310, 93.313, 93.350, 93.361, 93.393, 93.396, 93.840, 93.846, 93.847, 93.853, 93.855, 93.865, 93.866, 93.867.
• This funding opportunity was created on 2022-12-23.
• Applicants must submit their applications by 2023-03-01. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA PM 23 001

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