Opportunity Information: Apply for RFA PM 23 001
The National Institutes of Health (NIH), through the Office of the Director and its All of Us Research Program, offered this grant opportunity to help researchers make stronger, more innovative use of data housed in the All of Us Researcher Workbench. The overall aim is to advance research that aligns with high-priority mission areas across NIH Institutes, Centers, and Offices by encouraging projects that either apply established analytic approaches to existing All of Us data or push the field forward by creating new computational approaches that expand what can be learned from the dataset. This specific announcement uses the R21 mechanism and is labeled "Clinical Trial Not Allowed," meaning the work is intended to be exploratory and methods-focused rather than running interventional clinical trials.
This R21 opportunity is centered on developing new methods, models, and tools and then demonstrating their value by applying them to analyses within the All of Us Researcher Workbench environment. A key expectation is that the tools produced under this funding track are not just one-off scripts for a single research team, but resources that can be made broadly available to the wider scientific community. In practice, that means applicants are expected to think about usability, reproducibility, and portability within the Workbench context, so other researchers can adopt the new approach to accelerate discovery and expand the impact of the All of Us dataset.
NIH positioned this funding as one of two companion announcements. While this R21 is intended for new tool or method development plus application, a companion R03 announcement supports projects that analyze All of Us data using standard, established methods and approaches. Together, the pair of announcements covers both immediate scientific use of currently available data (R03) and longer-term capability building that improves how the community can analyze the data going forward (R21).
Eligibility is broad and includes many types of domestic applicants such as state, county, and local governments; special district governments; independent school districts; public and private institutions of higher education; federally recognized tribal governments; tribal organizations that are not federally recognized; public housing authorities; nonprofits with and without 501(c)(3) status; for-profit organizations (other than small businesses) and small businesses; and other entities. The announcement also explicitly highlights additional eligible applicant categories, including Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities, Asian American Native American Pacific Islander Serving Institutions, Tribally Controlled Colleges and Universities, eligible federal agencies, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and even non-U.S. entities (foreign organizations). This wide eligibility reflects the program's interest in expanding who participates in research using All of Us data and who contributes tools that make the data more accessible and useful.
Administrative details in the source information identify the opportunity as a discretionary NIH grant (Funding Opportunity Number RFA-PM-23-001) with an original closing date of March 1, 2023, and a creation date of December 23, 2022. The listing associates the opportunity with multiple CFDA numbers tied to NIH programs, underscoring that the scientific areas supported could span many NIH mission domains. While the summary provided does not list an award ceiling or the expected number of awards, the central message of the opportunity is clear: build and validate new analytic capabilities inside the All of Us Researcher Workbench, and ensure those capabilities can be shared so the broader research community can use them to generate insights from the All of Us dataset.Apply for RFA PM 23 001
- The National Institutes of Health in the education, food and nutrition, health, income security and social services sector is offering a public funding opportunity titled "Enhancing the Use of the All of Us Research Programs Data (R21 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121, 93.172, 93.173, 93.213, 93.233, 93.242, 93.273, 93.279, 93.286, 93.307, 93.310, 93.313, 93.350, 93.361, 93.393, 93.396, 93.840, 93.846, 93.847, 93.853, 93.855, 93.865, 93.866, 93.867.
- This funding opportunity was created on 2022-12-23.
- Applicants must submit their applications by 2023-03-01. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the purpose of this NIH funding opportunity?
This opportunity from the National Institutes of Health (NIH), through the Office of the Director and the All of Us Research Program, is intended to help researchers make stronger and more innovative use of data in the All of Us Researcher Workbench. The overall aim is to advance research aligned with high-priority mission areas across NIH Institutes, Centers, and Offices by supporting new analytic capabilities and demonstrating their value using All of Us data.
Which NIH program is offering this opportunity?
The opportunity is offered by NIH through the Office of the Director and its All of Us Research Program.
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is RFA-PM-23-001.
What grant mechanism does this announcement use?
This announcement uses the NIH R21 mechanism, which is positioned here for exploratory, methods-focused work involving development of new methods, models, and tools, plus demonstration through application within the All of Us Researcher Workbench.
Are clinical trials allowed under this announcement?
No. The announcement is labeled "Clinical Trial Not Allowed," meaning it is intended for exploratory and methods-focused activities rather than interventional clinical trials.
What types of projects are a good fit for this R21?
The R21 is centered on developing new methods, models, and tools and then demonstrating their value by applying them to analyses inside the All of Us Researcher Workbench environment. It supports projects that push the field forward by creating new computational approaches that expand what can be learned from the dataset.
Does this opportunity support analysis using only established methods?
This specific R21 is focused on new tool or method development plus application. A companion R03 announcement is described as supporting projects that analyze All of Us data using standard, established methods and approaches.
How does this R21 relate to the companion R03 announcement?
NIH described this R21 as one of two companion announcements. The R03 supports analyses of All of Us data using established methods (near-term use of available data), while the R21 supports longer-term capability building by developing and validating new analytic methods and tools that improve how the community can analyze the data going forward.
Where are the proposed tools and analyses expected to run?
The work is expected to be developed and demonstrated within the All of Us Researcher Workbench environment, with analyses conducted using data housed in the Workbench.
Is there an expectation that tools created will be shared beyond the applicant's team?
Yes. A key expectation is that tools produced are not one-off scripts meant only for a single research team, but resources that can be made broadly available to the wider scientific community.
What does NIH mean by tools being broadly available?
Based on the description provided, applicants are expected to consider usability, reproducibility, and portability within the Workbench context so other researchers can adopt the approach to accelerate discovery and expand the impact of the All of Us dataset.
What kinds of improvements is NIH trying to encourage through this funding?
NIH is encouraging both (1) the development of new computational approaches that expand what can be learned from the All of Us dataset and (2) stronger, more innovative use of existing Workbench data by advancing analytic capabilities that can be reused by the broader research community.
What are examples of the kinds of deliverables emphasized in the description?
The description emphasizes methods, models, and tools that can be demonstrated through Workbench analyses and are designed for community adoption, rather than one-off scripts limited to a single team.
Who is eligible to apply?
Eligibility is broad and includes many types of applicants, such as state, county, and local governments; special district governments; independent school districts; public and private institutions of higher education; federally recognized tribal governments; tribal organizations that are not federally recognized; public housing authorities; nonprofits with and without 501(c)(3) status; for-profit organizations (other than small businesses) and small businesses; and other entities.
Are minority-serving institutions specifically mentioned as eligible?
Yes. The announcement explicitly highlights additional eligible applicant categories, including Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities, Asian American Native American Pacific Islander Serving Institutions, Tribally Controlled Colleges and Universities, and others.
Are federal agencies eligible to apply?
Yes. Eligible applicant categories explicitly include eligible federal agencies.
Are faith-based or community-based organizations eligible?
Yes. The eligibility list explicitly includes faith-based or community-based organizations.
Are U.S. territories or possessions eligible?
Yes. The eligibility list includes U.S. territories or possessions.
Are foreign (non-U.S.) organizations eligible to apply?
Yes. The eligibility list includes non-U.S. entities (foreign organizations).
What is the closing date and creation date listed for this opportunity?
The source information identifies an original closing date of March 1, 2023, and a creation date of December 23, 2022.
What type of grant is this described as?
It is identified as a discretionary NIH grant.
Does the provided summary include the award ceiling or the expected number of awards?
No. The summary provided does not list an award ceiling or the expected number of awards.
What scientific areas could be supported under this funding opportunity?
The listing is associated with multiple CFDA numbers tied to NIH programs, and the description notes that supported scientific areas could span many NIH mission domains, particularly those aligned with high-priority mission areas across NIH Institutes, Centers, and Offices.
What is the core message of this funding opportunity?
The central message is to build and validate new analytic capabilities inside the All of Us Researcher Workbench and ensure those capabilities can be shared so the broader research community can use them to generate insights from the All of Us dataset.
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| NIH Science Education Partnership Award (SEPA) (R25 - Clinical Trial Not Allowed) Apply for PAR 23 137 Funding Number: PAR 23 137 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $250,000 |
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| HEAL Initiative: HEAL KIDS (Knowledge, Innovation and Discovery Studies) Pain: Acute Pain Clinical Trials Program (U01 Clinical Trial Required) Apply for RFA HD 24 011 Funding Number: RFA HD 24 011 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
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| Advancing HIV service delivery through pharmacies and pharmacists (R01 Clinical Trial Optional) Apply for RFA MH 25 185 Funding Number: RFA MH 25 185 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
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| HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed) Apply for RFA NS 25 023 Funding Number: RFA NS 25 023 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $350,000 |
| Time-Sensitive Evaluation of Policies Affecting Health Behaviors and Chronic Disease Risk (R01-Clinical Trial Not Allowed) Apply for PAR 25 312 Funding Number: PAR 25 312 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
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