Opportunity Information: Apply for PA 17 147
The NIH funding opportunity titled "Development of Highly Innovative Tools and Technology for Analysis of Single Cells (SBIR) (R43/R44)" (PA-17-147) is a discretionary grant program designed to support small businesses that want to build and validate next-generation technologies for single-cell analysis. The core idea is to push beyond current methods so researchers can study biology at the level of individual cells, rather than averaging signals across many cells. By doing that, these tools can reveal how cell populations differ from one another, how cellular states change over time, and how cells communicate and interact in complex tissues. The long-term goal is practical: to move promising inventions toward commercialization so they can be broadly adopted across biomedical research and, ultimately, improve how health and disease are understood at a mechanistic level.
This FOA specifically targets innovations that deliver clear, measurable improvements over existing single-cell technologies. Applicants are expected to spell out what the current state of the art looks like and use that as a benchmark for comparison, rather than making vague claims of novelty. The proposed approach should substantially outperform existing tools in one or more meaningful dimensions, such as sensitivity (detecting very small amounts of a signal), selectivity (distinguishing closely related targets), spatiotemporal resolution (capturing where something happens in a cell or tissue and how it changes over time), scalability (handling larger numbers of cells efficiently), multiplexing (measuring many molecular features at once), or enabling non-destructive measurements (so cells can potentially be tracked, perturbed, or used downstream after analysis). In practice, this can include new platforms for single-cell genomics, transcriptomics, proteomics, epigenomics, imaging-based assays, microfluidics, functional profiling tools, or integrated hardware-software systems that make single-cell measurements more accurate, higher-throughput, or more biologically informative.
The mechanism is SBIR, using the R43/R44 pathway, which generally corresponds to a phased development structure that fits technology maturation and commercialization goals. While the FOA text here does not list award caps or expected award counts, the intent is clearly development-focused: proposing, building, and validating tools robustly enough to be useful for real research settings and attractive for commercialization. A companion opportunity exists for the STTR mechanism (PA-17-148), which is relevant for teams structured around formal small business and research institution partnerships under STTR rules, but this particular announcement is the SBIR version for eligible small business concerns.
Eligibility is limited to small businesses. Foreign institutions (non-U.S. entities) are not eligible to apply, and non-U.S. components of U.S. organizations are also not eligible to apply. However, the FOA notes that "foreign components" as defined by the NIH Grants Policy Statement may be allowed, which typically means certain project elements can be performed abroad if they are well-justified, clearly described, and comply with NIH policy, but the applicant organization itself must still be an eligible U.S. small business under SBIR rules.
Administratively, the program is run by the National Institutes of Health, and it is associated with multiple CFDA numbers spanning NIH institutes and centers (including 93.113, 93.121, 93.213, 93.242, 93.279, 93.350, 93.393 through 93.399, 93.846, 93.847, 93.859, and 93.867), reflecting that single-cell technology development is relevant across many disease areas and research domains. The announcement was created on 2017-02-01, with an original closing date listed as 2020-01-05 in the provided source data. Overall, the opportunity is aimed at small companies that can clearly articulate the limitations of current single-cell tools, propose a credible and innovative leap forward, and show a development and validation plan that supports eventual commercialization and broad utility in biomedical research.Apply for PA 17 147
- The National Institutes of Health in the education, environment, food and nutrition, health sector is offering a public funding opportunity titled "Development of Highly Innovative Tools and Technology for Analysis of Single Cells (SBIR) (R43/R44)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.213, 93.242, 93.279, 93.350, 93.393, 93.394, 93.395, 93.396, 93.399, 93.846, 93.847, 93.859, 93.867.
- This funding opportunity was created on 2017-02-01.
- Applicants must submit their applications by 2020-01-05. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses.
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| Administrative Supplements for Validation Studies of Analytical Methods for Dietary Supplement Constituents (Admin Supp - Clinical Trial Not Allowed) Apply for PA 18 818 Funding Number: PA 18 818 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health Funding Amount: Case Dependent |
| Methods to Improve Reproducibility of Human iPSC Derivation, Growth and Differentiation (SBIR) (R44 Clinical Trial Not Allowed) Apply for RFA GM 19 001 Funding Number: RFA GM 19 001 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health Funding Amount: $375,000 |
| SBIR/STTR Commercialization Readiness Pilot (CRP) Program Technical Assistance (SB1, R44) Clinical Trial Not Allowed Apply for PAR 19 334 Funding Number: PAR 19 334 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health Funding Amount: Case Dependent |
| USAID Cambodia Integrated Early Childhood Development Activity Apply for 72044220RFA00001 Funding Number: 72044220RFA00001 Agency: Cambodia USAID-Phnom Penh Category: Education, Environment, Food and Nutrition, Health Funding Amount: $15,000,000 |
| Community Interventions to Address the Consequences of the COVID-19 Pandemic among Health Disparity and Vulnerable Populations (R01- Clinical Trial Optional) Apply for PAR 20 237 Funding Number: PAR 20 237 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health Funding Amount: $500,000 |
| SBIR/STTR Commercialization Readiness Pilot (CRP) Program Technical Assistance (SB1, Clinical Trial Not Allowed) Apply for PAR 20 128 Funding Number: PAR 20 128 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health Funding Amount: Case Dependent |
| Validation Studies of Analytical Methods for Dietary Supplement Constituents (Admin Supp - Clinical Trial Not Allowed) Apply for PA 20 252 Funding Number: PA 20 252 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health Funding Amount: Case Dependent |
| Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional) Apply for PA 20 272 Funding Number: PA 20 272 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health Funding Amount: Case Dependent |
| NIH Support for Conferences and Scientific Meetings (Parent R13 Clinical Trial Not Allowed) Apply for PA 21 151 Funding Number: PA 21 151 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health Funding Amount: Case Dependent |
| Identification and Characterization of Bioactive Microbial Metabolites for Advancing Research on Microbe-Diet-Host Interactions (R01 Clinical Trial Not Allowed) Apply for PAR 21 253 Funding Number: PAR 21 253 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health Funding Amount: Case Dependent |
| Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC) Postdoctoral Career Transition Award to Promote Diversity (K99/R00 - Independent Clinical Trial Required) Apply for PAR 21 272 Funding Number: PAR 21 272 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health Funding Amount: Case Dependent |
| Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC) Postdoctoral Career Transition Award to Promote Diversity (K99/R00 Independent Clinical Trial Not Allowed) Apply for PAR 21 271 Funding Number: PAR 21 271 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health Funding Amount: Case Dependent |
| Lasker Clinical Research Scholars Program (Si2/R00 Clinical Trial Optional) Apply for PAR 22 078 Funding Number: PAR 22 078 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health Funding Amount: Case Dependent |
| Specialized Centers of Research Excellence (SCORE) on Sex Differences (U54 Clinical Trial Optional) Apply for RFA OD 22 014 Funding Number: RFA OD 22 014 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health Funding Amount: Case Dependent |
| Lasker Clinical Research Scholars Program (Si2/R00 Clinical Trial Optional) Apply for PAR 23 156 Funding Number: PAR 23 156 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health Funding Amount: Case Dependent |
| SBIR/STTR Commercialization Readiness Pilot (CRP) Program Technical Assistance and Late Stage Development (SB1, Clinical Trial Not Allowed) Apply for PAR 23 219 Funding Number: PAR 23 219 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health Funding Amount: Case Dependent |
| PHS 2023-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed) Apply for PA 23 232 Funding Number: PA 23 232 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health Funding Amount: Case Dependent |
| Intervention Research to Improve Native American Health (R01 Clinical Trial Optional) Apply for PAR 23 298 Funding Number: PAR 23 298 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health Funding Amount: $500,000 |
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