Opportunity Information: Apply for RFA NS 19 002
The BRAIN Initiative: Team-Research BRAIN Circuit Programs (TeamBCP) funding opportunity (RFA-NS-19-002) is a National Institutes of Health (NIH) cooperative agreement (U19) designed to support large, integrated, interdisciplinary research programs that investigate how neural circuits give rise to behavior. The emphasis is on team science: multi-component projects that bring together complementary expertise and advanced technologies to produce substantial, meaningful outcomes on a roughly five-year timeline, with the possibility of one competing renewal. The opportunity is framed around understanding core, overarching principles of circuit function, but applicants are expected to ground those principles in specific neural systems tied to major domains of behavior and brain function, such as sensation and perception, emotion and motivation, cognition and decision-making, motor control, communication, and homeostatic regulation.
A central expectation is that projects will use theory- or model-driven experimental design rather than purely exploratory work. Applicants are asked to articulate the theoretical constructs guiding the research and to generate predictive models as concrete deliverables, meaning the work should culminate in models that can make testable predictions about circuit dynamics and behavior. The FOA encourages quantitative and mechanistic modeling approaches where they fit the scientific question, reflecting a strong preference for tight coupling between computational/theoretical frameworks and experimental validation. In practical terms, teams are expected to systematically control stimuli and/or behavior while actively recording and/or manipulating dynamic neural activity patterns, and then measure resulting behavioral or perceptual outcomes. This implies integrated pipelines that connect experimental control, neural measurement and perturbation, and behavioral readouts in ways that allow causal inference about circuit function.
The program is also structured to push the field toward shared and improving infrastructure for data and analysis. Awardees must manage their data and analysis methods within a prototype framework that will be developed and used within the proposed U19 project, and then exchanged with other U19 teams so that the framework can be refined and further developed across the community of awardees. This requirement signals that beyond producing scientific findings, applicants should plan for rigorous, organized, and transferable data/analysis practices, including workflows that can be shared and iterated collaboratively among funded programs.
In terms of scientific scope, the FOA allows a wide range of model systems and explicitly permits using multiple species, from invertebrates through humans, as long as choices are clearly justified by the circuit questions and behavioral phenomena being targeted. This flexibility supports cross-species strategies that can link mechanistic circuit dissection in tractable systems to translational or human-relevant insights where appropriate. Because this is a U19 cooperative agreement and the title specifies "Clinical Trial Required," applicants should also be prepared for an active partnership model with NIH program staff and for meeting the specific expectations that accompany clinical trial involvement when applicable to the proposed research.
Eligible applicants are broad and include many types of domestic organizations and institutions, such as state, county, and local governments; public and private institutions of higher education; federally recognized tribal governments and other tribal organizations; independent school districts; special district governments; public housing authorities/Indian housing authorities; nonprofit organizations (with or without 501(c)(3) status); for-profit organizations (other than small businesses); and small businesses, with additional eligibility details referenced in the full announcement. The sponsoring agency is the U.S. Department of Health and Human Services (HHS) through NIH, and the opportunity is associated with multiple CFDA program numbers (93.173, 93.213, 93.242, 93.273, 93.279, 93.286, 93.313, 93.853, 93.865, 93.866, 93.867), reflecting the multi-institute, multi-program nature often seen in BRAIN Initiative efforts. The FOA anticipated making about five awards. The award ceiling is listed as 0, which typically indicates that a fixed cap is not specified in the summary and that budgets should instead be justified and scaled to the needs of a multi-component, interdisciplinary program.
Budgeting and team composition are expected to match the ambition of a coordinated program rather than a single-lab project. Applications should propose multi-component teams that cross disciplinary boundaries and integrate expertise from areas like neurobiology, statistics, physics, mathematics, engineering, computer science, and data science, as appropriate for the scientific aims and technical approach. Overall, the opportunity is aimed at research programs that combine cutting-edge tools, rigorous experimental control, and strong theoretical grounding to explain how CNS circuits operate dynamically to generate behavior, while also producing transferable models and sharable data/analysis frameworks that can accelerate progress across the broader neuroscience community.Apply for RFA NS 19 002
- The Department of Health and Human Services, National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "BRAIN Initiative: Team-Research BRAIN Circuit Programs - TeamBCP (U19 Clinical Trial Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.173, 93.213, 93.242, 93.273, 93.279, 93.286, 93.313, 93.853, 93.865, 93.866, 93.867.
- This funding opportunity was created on Aug 29, 2018.
- Applicants must submit their applications by Oct 30, 2020. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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| BRAIN Initiative: Team-Research BRAIN Circuit Programs - TeamBCP (U19 Clinical Trial Not Allowed) Apply for RFA NS 19 003 Funding Number: RFA NS 19 003 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
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| Data Coordinating and Operations Center for the ECHO IDeA States Pediatric Clinical Trials Network - 2 (U24 - Clinical Trial Required -Infrastructure) Apply for RFA OD 19 025 Funding Number: RFA OD 19 025 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
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| BRAIN Initiative: Non-Invasive Neuromodulation - Mechanisms and Dose/Response Relationships for Targeted CNS Effects (R01) Apply for RFA MH 17 245 Funding Number: RFA MH 17 245 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
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